After you've spent some time on the slot machines, move on to the Blackjack table, and start by just observing. Blackjack has the best odds of winning, with a house edge of just 1 percent in most casinos, Bean said. Plus, you are playing against only the dealer, not hooded poker champions.

Blackjack has the best odds of winning, with a house edge of just 1 percent in most casinos, Bean said. Plus, you are playing against only the dealer, not hooded poker champions.

What casino game has the best odds? Video poker can provide the best odds in a casino, depending on the version of the paytable. However, blackjack is generally regarded as having the best casino odds when using basic strategy. This can help lower the house edge to around 0.50%.